A Q methodology study on divergent perspectives on CRISPR-Cas9 in the Netherlands

Abstract Background CRISPR-Cas9, a technology enabling modification of the human genome, is developing rapidly. There have been calls for public debate to discuss its ethics, societal implications, and governance. So far, however, little known about attitudes on CRISPR-Cas9. This study contributes better understanding perspectives by exploring various holistic Dutch citizens Methods used Q methodology identify different (N = 30) use The Q-sort method aims at segmenting audiences based structural characteristics their perspectives. Participants individually ranked 32 statements CRISPR-Cas9 discussed rankings in small groups. By-person factor analysis was performed using PQMethod. Participants’ contributions discussions were further make sense audience segments identified. Results Five identified: (1) pragmatic optimism (2) concerned scepticism; (3) normative optimism; (4) enthusiastic support; (5) benevolent generalism. Each perspective represents unique position motivated ranking rationales. Sorting rationales included improving health, preventing negative impacts society, fear slippery slope. Overall, there broad, but not universal support medical uses Conclusions Research should prioritise broadly supported applications technology. debates uses, broader governance are recommended. A discourse that includes all can contribute embedding future society. shows followed group enables meaningfully discourses research.